Study on Syntheses and Antimicrobial Activities of Derivatives of 3-Amino-2-methyl-quinazolin-4-(3H)-one

Chhabra, G. S. and Tiwari, Ravi (2022) Study on Syntheses and Antimicrobial Activities of Derivatives of 3-Amino-2-methyl-quinazolin-4-(3H)-one. In: New Innovations in Chemistry and Biochemistry Vol. 7. B P International, pp. 112-118. ISBN 978-93-5547-478-0

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3-amino-2-methyl-quinazolin-4-(3H)-one (1) was synthesised in this study by reacting N-acetyl anthranilic acid with acetic anhydride and then treating the mixture with hydrazine hydrate in pyridine. Compound 1 yields 3-chloroethanoylamino-2-methyl-quinazolin-4-(3H)-one(2) when treated with chloro acetyl chloride. By reacting the substituted derivative 2 with aliphatic and aromatic secondary amines, the final compounds 4a-g were obtained. The elemental analysis, IR, and 1H NMR data were used to determine the structural assignment of this compound 4a-g. The compounds were tested for growth inhibitory action in vitro by determining the minimal inhibitory concentration. inhibitory concentration against various bacterial and fungal strains Compounds 4a, 4b, 4e, and 4g have the highest antibacterial activity, while compounds 4a, 4b, 4d, and 4e have the strongest antifungal activity.

Item Type: Book Section
Subjects: Eprints STM archive > Chemical Science
Depositing User: Unnamed user with email admin@eprints.stmarchive
Date Deposited: 18 Oct 2023 05:03
Last Modified: 18 Oct 2023 05:03

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