Multiple Myeloma Presenting in Unusual Extramedullary Sites in a 62 Year Old Female from Kigali, Rwanda: Case Report

Amendezo, Etienne and Kavabushi, Patrick and Nizeyimana, Theoneste and Ngabonziza, Issa and Niyongabo, Patrick and Tobi, Kingsley and Imuragire, Julienne and Nshizirungu, Jean and Kyokunda-Tumwine, Lynnette (2018) Multiple Myeloma Presenting in Unusual Extramedullary Sites in a 62 Year Old Female from Kigali, Rwanda: Case Report. International Journal of Medical and Pharmaceutical Case Reports, 11 (1). pp. 1-8. ISSN 2394109X

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Abstract

Introduction: Multiple myeloma (MM) is a malignant hematological tumor that mainly manifests as osseous lesions in the bone marrow and skeletal bones. It rarely presents in extramedullary sites. Patients with extramedullary disease have been noted to have advanced stage disease with poor prognosis. We describe the clinical, radiological and pathological manifestations of a 62 year old Rwandan female who presented with extramedullary plasmacytoma involving multiple sites including the pleura, pancreas and gall bladder.

Case Presentation: A 62 year old Rwandan female presented with a three week history of intractable post-prandial vomiting, nausea, progressive weight loss, generalized body pain and limb weakness. Our diagnostic work-up showed soft tissue tumors involving multiple organs particularly pleura, pancreas and gall bladder along with diffuse lytic bone lesions in the ribs, spine and pelvis. Laboratory tests showed increased serum amylase, lipase, calcium, lactate dehydrogenase and CA125. Histopathology of the core biopsy of the pleura showed infiltration of monotonous atypical plasma cells. A diagnosis of MM with multiple extramedullary lesions was made. The patient initially improved and reached a partial response on bortezomib, dexamethasone and lenalidomide. However, five months after the initial diagnosis, she died from complications of the disease.

Conclusion: MM may be challenging to diagnose when it presents in unusual sites as extramedullary plasmacytomas.

Item Type: Article
Subjects: Eprints STM archive > Medical Science
Depositing User: Unnamed user with email admin@eprints.stmarchive
Date Deposited: 11 May 2023 09:30
Last Modified: 12 Jan 2024 07:11
URI: http://public.paper4promo.com/id/eprint/123

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