Overview of Diabetes as a Risk Factor for Developing Dementia: A Systematic Review

Alrefaei, Ahmed Yassin and Alanazi, Yasir Wadi Alngzi and Alanazi, Muhammad Sari Zahzum and Alshahrani, Mohammed Saeed (2023) Overview of Diabetes as a Risk Factor for Developing Dementia: A Systematic Review. Asian Journal of Medicine and Health, 21 (12). pp. 21-29. ISSN 2456-8414

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Background: There is debate over the relationship between diabetes and the main forms of dementia. The cognitive alterations associated with type 2 diabetes (T2D) mostly impact mental flexibility, mental speed, and learning and memory.

Objectives: To ascertain the degree of the link between diabetes and dementia, we thoroughly reviewed papers on the incidence of dementia in individuals with diabetes mellitus in this study.

Methods: PubMed, SCOPUS, Web of Science, and Science Direct were systematically searched for relevant literature. Rayyan QRCI was employed throughout this comprehensive process.

Results and Interpretation: We included ten studies with a total of 173797 participants, and 78828 (45.4%) were males. All of the included studies were prospective cohorts. For diabetic patients, early-onset diabetes, poor glycemic management, and diabetes status are risk factors for dementia development. There was also a higher chance of dementia development in those with mild to severe motor cognitive impairment and hereditary variables. Longitudinal studies that involve comprehensive evaluations of comorbid diseases and diabetes-related variables, as well as rigorous assessments of cognition—ideally in conjunction with neuroimaging—will be necessary for this process. This method will work best with large population-based cohort studies of older adults with diabetes and with longitudinal studies of at-risk groups that look at the development of diabetes, metabolic syndrome, vascular disease, and cognitive decline.

Item Type: Article
Subjects: Eprints STM archive > Medical Science
Depositing User: Unnamed user with email admin@eprints.stmarchive
Date Deposited: 12 Dec 2023 06:45
Last Modified: 12 Dec 2023 06:45
URI: http://public.paper4promo.com/id/eprint/1683

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