G-Quadruplex and Ligand Interactions

Amit, Patnaik and Anita, Sinha and Vinay, Oraon and Duryodhan, Sahu (2023) G-Quadruplex and Ligand Interactions. In: Socio-Scientific Interaction in Diabetes and Cancer and Its Management. B P International, pp. 330-337. ISBN 978-81-968135-0-5

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Designing ligands to interact with G-quadruplex (G4) of DNA is challenging due to the complexity of G4 structures and the lack of efficient experimental methods to characterize G4/ligand interactions. Existing methods can be categorized into structure-based (e.g., CD, NMR, X-ray crystallography), affinity-based (e.g., SPR, ITC, MS), and high-throughput (e.g., FRET, G4-FID, affinity chromatography, microarrays) approaches, each with its own advantages and disadvantages. High-throughput methods are emerging as a promising alternative to traditional methods for screening and designing new G4 ligands, as they are faster and more cost-effective.

G4s are found in both DNA and RNA and play an important role in a variety of physiological processes, including cancer and neurological disorders. Targeting G4s with ligands is a promising therapeutic strategy for these diseases. A significant number of G4 ligands have been developed and investigated, and most of them are deposited in the G4 Ligands Database 2.1 (http://www.g4ldb.com/).

Item Type: Book Section
Subjects: Eprints STM archive > Medical Science
Depositing User: Unnamed user with email admin@eprints.stmarchive
Date Deposited: 12 Dec 2023 10:08
Last Modified: 12 Dec 2023 10:08
URI: http://public.paper4promo.com/id/eprint/1700

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