Preparation of Novel Dihydrophthalazinyl Phenylamide Derivatives and their Anti-Microbial Evaluation

Boddapati, S. N. Murthy and Saketi, Jaganmohana Rao and Kola, A. Emmanuel and Gorumutchu, Giri Prasad (2024) Preparation of Novel Dihydrophthalazinyl Phenylamide Derivatives and their Anti-Microbial Evaluation. In: Recent Developments in Chemistry and Biochemistry Research Vol. 3. B P International, pp. 105-119. ISBN 978-81-973053-6-8

Full text not available from this repository.


Phthalazine derivatives are an essential component of biological systems that serve as a structural template for biologically active molecules. In this chapter, Novel N-(4-(1,2-dihydrophthalazin-1-yl) phenyl) amides were synthesized in good yields, beginning with inexpensive and easily accessible phthalic anhydride using Pd (OAc)2 catalyzed Suzuki-mayura coupling and N-acylation reactions as key steps. All the prepared compounds were characterized by various spectroscopic techniques such as 1H NMR, 13C NMR, IR, and LCMS and all the data showed good agreement with the predicted structures. Additionally, the produced compounds' in vitro anti-microbial activity was examined. In comparison to Xanthomonas campestris, the target compounds 7i, 7f, and 7a demonstrated superior activity. In contrast, the compounds 7j, 7a, and 7h demonstrated excellent activity against Bacillus megaterium. Escherichia coli was effectively inhibited by compounds 7j and 7a. The obtained N-(4-(1,2-dihydrophthalazin-1-yl) phenyl) amide derivatives offer an intriguing profile in the field of antimicrobial research.

Item Type: Book Section
Subjects: Eprints STM archive > Chemical Science
Depositing User: Unnamed user with email admin@eprints.stmarchive
Date Deposited: 10 May 2024 08:34
Last Modified: 10 May 2024 08:34

Actions (login required)

View Item
View Item