A Rare Case of IgA-mediated Autoimmune Hemolytic Anemia in a Young Adult

Alameri, Majid and Alnuaimi, Abdullah (2016) A Rare Case of IgA-mediated Autoimmune Hemolytic Anemia in a Young Adult. British Journal of Medicine and Medical Research, 17 (9). pp. 1-5. ISSN 22310614

[thumbnail of Alameri1792016BJMMR26583.pdf] Text
Alameri1792016BJMMR26583.pdf - Published Version

Download (553kB)

Abstract

A 21-year-old previously healthy male presented with unexplained intravascular hemolysis. Patient had anemia, elevated serum indirect bilirubin, elevated LDH, reticulocytosis, decreased haptoglobin and spherocytosis. Initial Laboratory investigations revealed a negative direct antiglobulin test (DAT), suggesting a Coombs-negative hemolytic anemia. Additional testing with monospecific anti-IgA was strongly positive. Autoimmune hemolytic anemia due to warm-reacting IgA autoantibodies is very rare and presents with "Coombs negative" autoimmune hemolytic anemia. A diagnosis of idiopathic IgA-only-associated warm AIHA was made after extensive investigations. Treatment included transfusion of multiple ABO/RH-D compatible typed red cell concentrates and administration of high-dose steroids. This case report will highlight the initial clinical presentation, panel of investigations for diagnosis; course of treatment and follow up with a brief literature review of the pathophysiologic mechanism and suggested treatment modalities for this rare IgA-induced warm AIHA.

Item Type: Article
Subjects: Eprints STM archive > Medical Science
Depositing User: Unnamed user with email admin@eprints.stmarchive
Date Deposited: 06 Jun 2023 08:57
Last Modified: 13 Jan 2024 04:32
URI: http://public.paper4promo.com/id/eprint/435

Actions (login required)

View Item
View Item