Isolation, Characterization and Antimicrobial Activity of 3β, 22E-Stigmasta-5, 22-dien-3-ol from the Aerial Part of Aeschynomene uniflora E. Mey

Achika, J. I. and Ndukwe, G. I. and Ayo, R. G. (2016) Isolation, Characterization and Antimicrobial Activity of 3β, 22E-Stigmasta-5, 22-dien-3-ol from the Aerial Part of Aeschynomene uniflora E. Mey. British Journal of Pharmaceutical Research, 11 (5). pp. 1-8. ISSN 22312919

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Abstract

Objectives: To isolate, characterize and determine the antimicrobial activity of bioactive compounds present in the petroleum ether fraction of the aerial parts of Aeschynomene uniflora E. Mey.

Methods: Aeschynomene uniflora was collected, identified, dried and pulverized. The pulverized plant material was subjected to Soxhlet extraction using petroleum ether. The petroleum ether extract was subjected to chromatographic techniques which yielded J1. J1 was then subjected to antimicrobial screening using some selected microorganisms. J1 was characterized using IR and NMR spectroscopic techniques.

Results: The structure of the isolated compound was established to be 3β, 22E-Stigmasta-5, 22-dien-3-ol (stigmasterol) using spectroscopic analysis (IR, 1D-NMR). The isolated compound showed significant antimicrobial activity on some selected microorganisms.

Conclusion: The results could justify the use of the aerial parts of Aeschynomene uniflora in traditional herbal medicine for the treatment of various microbial diseases.

Item Type: Article
Subjects: Eprints STM archive > Medical Science
Depositing User: Unnamed user with email admin@eprints.stmarchive
Date Deposited: 06 Jul 2023 04:54
Last Modified: 17 Jan 2024 04:24
URI: http://public.paper4promo.com/id/eprint/559

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