Evaluation of Non Enzymatic Status in Antioxidant Capital in Senegalese Type 2 Diabetics

Thiam, Souleymane and Toure, M. and Samba, A. and Ardja, A. A. and Ndiaye, A. and Coly, N. and Soumah, I. Y. and Diedhiou, F. and Agossou, H. H. H. and Tounkara, A. R. and Dia, F. K. S. T. and Ba, R. and Faye, I. and Gueye, M. M. and Diouf, N. N. and Cisse, F. and Diatta, A. and Diallo, F. (2023) Evaluation of Non Enzymatic Status in Antioxidant Capital in Senegalese Type 2 Diabetics. Asian Journal of Biochemistry, Genetics and Molecular Biology, 14 (3). pp. 1-8. ISSN 2582-3698

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Oxidative stress appears very early in the history of type 2 diabetes complications. It is associated to glucose oxidation but also to lipid peroxidation. This stress can be accentuated by a decrease in the antioxidant capacities in diabetics, especially if there are other comorbidities. The objective of this study was to evaluate the antioxidant capacity of Senegalese type 2 diabetics and to identify the associated risk factors.

We conducted a prospective study in 40 persons with type 2 diabetes. Factors related to age, sex, BMI, and BP were determined. For biological parameters, we measured blood glucose at empty stomach, glycated haemoglobin, total cholesterol, HDL, triglycerides and LDL, urea and creatinine, uric acid, albumin, total bilirubin, copper, and zinc.

The mean age of the population was 58±11.24 years with a predominance of subjects aged over 60 (52.5%). The sex ratio was 1.11 with 52.5% male. Antioxidant capital was reduced in 60% of patients, with a predominance of women (35%). This reduction was marked by hypoalbuminemia (32.5%), hypozincemia (22.5) and an increase in the Cu/Zn ratio (30%). A strong correlation was found between the Cu/Zn ratio and total cholesterol (r=0.911; p<0.0001) as well as LDL (r=1; p=0.0001). Dyslipidaemia was found to be the most associated comorbidity with decreased oxidative capacity with an RR of 1.4 (CI=0.79-2.35) for total hypercholesterolemia and an RR of 1.6 (CI=0.75-3.71) for hypertriglyceridemia.

The antioxidant capital is reduced in type 2 diabetics, especially in dyslipidaemia conditions. Hygienic dietary measures and supplementation with trace elements such as zinc should prevent the complications of oxidative stress in diabetics.

Item Type: Article
Subjects: Eprints STM archive > Biological Science
Depositing User: Unnamed user with email admin@eprints.stmarchive
Date Deposited: 13 Jun 2023 05:55
Last Modified: 02 Nov 2023 06:16
URI: http://public.paper4promo.com/id/eprint/661

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