UTILITY OF ENAMINONITRILE IN THE SYNTHESIS OF NOVEL HETEROCYCLES BEARING PYRAZOLE MOIETY AND THEIR ANTIMICROBIAL AND CYTOTOXIC ACTIVITY ASSESSMENT

Enaminonitrile derivatives 1a,b were used as a versatile material for the synthesis of different heterocyclic compounds such as pyrazoloacetamide, pyrazolopyrimidinone, pyrazolobenzamide, pyrazolopyrimidines, pyrazolothiazinethiones, pyrazolopyrimidinedithiones, pyrazolocyanoacetamide, pyrazolopyrazoles, tetrazolopyrazoles, pyrazolotetrazolopyrimidines, and pyrazolotetrazolodiazepine derivatives, through the reaction with different electrophiles and nucleophiles. The newly synthesized compound were tested against gram positive and gram negative bacteria, fungi and two human tumor cell lines.