L-Proline Catalyzed Transamidation of Thioamides with Amines

L-Proline catalyzed transthioamidation of primary thioamides with amines under solvent-free conditions has been characterised. The catalyst L-proline is commercially available and required low catalyst loading. L-Proline promotes the reaction through hydrogen bond formation with amines. A wide variety of amines can be transthioamidated with yields of up to 97%. The reactions proceed through ionic pathway under neat conditions.