TERMINAL MOIETY DEPENDENCY OF THE CYTOTOXIC POTENCY OF PELLYNOL A FROM Halichondria Sp.

Pellynol A was isolated from the Et2O extract of the marine sponge Halichondria Sp. collected in Okinawa, Japan. The potency of Pellynol A was determined to be dependent on the presence of OH groups on its terminal moiety by preparing it mono, di and triacetate derivatives and subjecting them to anti-proliferation test against HeLa. It revealed that the more substituted the hydroxyl group on the chain, the less potent the derivatives. The Planar structures of the isolated and synthesized compounds’ structures were determined using a combination of 2D-NMR and mass spectrometric analysis.