Effects of Anticancerous Drugs- EMS and MMS in Induced Diabetic Mouse: Differential Response of Biochemical Parameters and Dose Effect Relationship of Chromosomal Aberrations

Diabetes is one among the top ten leading killers of human population. Epidemiological studies revealed that diabetes is being increased due to exposure to pollutants. Alkylating agents are one such group of pollutants, which are also being used as anticancer agents. Even though, we use alkylating agents as antineoplastics, their influence in diabetic condition in human has not been worked out. Hence, mouse as a model organism was used to induce diabetic condition and the same has been employed to test the well known two alkylating agents such as ethyl methanesulfonate (EMS) and methyl methanesulfonate (MMS). These agents were tested to understand their influence on biochemical parameters and on chromosomes. The results have revealed that these agents drastically affect the different biochemical parameters. Further, for the first time it has been demonstrated that these agents induce less chromosomal aberrations in diabetic mouse compared to non-diabetic. These results are discussed with relevant literature.