The role of diabetic foot treatment in improving left ventricular function: Insights from global longitudinal strain echocardiography

Ashoobi, Mohammad Taghi and Hemmati, Hosein and Moayerifar, Maziar and Moayerifar, Mani and Gholipour, Mahboobeh and Motiei, Mahsa and Yazdanipour, Mohammad Ali and Eslami Kenarsari, Habib and Onwukwe, Chikezie Hart (2024) The role of diabetic foot treatment in improving left ventricular function: Insights from global longitudinal strain echocardiography. PLOS ONE, 19 (3). e0299887. ISSN 1932-6203

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Abstract

We decided to evaluate the effect of treatment of diabetic foot ulcers in improving heart function by strain echocardiography than conventional transthoracic echocardiography. This prospective cross-sectional study included patients with diabetic foot ulcer (DFU). Conventional and two-dimensional strain echocardiography performed before and after three months diabetic foot treatment. Then, we compared the echocardiographic parameters including left ventricular ejection fraction (LV-EF), left ventricular global longitudinal strain (LV-GLS). Multivariate and univariate logistic regression analysis were performed to find which variable was mainly associated with LV-GLS changes. 62 patients with DFU were conducted. After echocardiography, all patients underwent surgical or non-surgical treatments. Three months after the treatment, LV-EF was not significantly different with its’ primary values (P = 0.250), but LV-GLS became significantly different (P<0.05). In the multivariate logistic regression analysis, with the increase in the grade of ulcer, LV-GLS improved by 6.3 times. Not only the treatment of DFU helps to control adverse outcomes like infection, limb loss and morbidity but also it enhances cardiac function. Of note, strain echocardiography found to be a better indicator of myocardial dysfunction than LV-EF. These findings make a strong reason for the routine assessment of cardiac function in patients with DFU.

Item Type: Article
Subjects: Eprints STM archive > Biological Science
Depositing User: Unnamed user with email admin@eprints.stmarchive
Date Deposited: 30 Mar 2024 12:30
Last Modified: 30 Mar 2024 12:30
URI: http://public.paper4promo.com/id/eprint/1909

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