Drug Release Modification by Using Citric Acid and Glycerol Cross-linked Derivatives of Cashew (Anacardium occidentale L.) Gum

A derivative of cashew gum (CrosCCG) developed by cross-linking the gum with two cross-linking agents, citric acid and glycerol, has been used to modify drug release in Venlafaxine Hydrochloride tablets. Wet granulation method was used to formulate the tablets using hydroxypropyl methylcellulose (HPMC ER K100) as a binder at 7.5%w/w. Increasing concentrations of the derivative was used to modify the drug release. The granules and the tablets formed were assessed by being subjected to the prescribed official tests. CrosCCG used at concentrations of 10 %w/w or lower enhanced drug release while concentrations above 10%w/w delayed drug release.