Shpakov, Alexander O. (2013) Peptides Corresponding to Intracellular Regions of GPCR as a New Generation of Selective Drugs. International Journal of Biochemistry Research & Review, 3 (4). pp. 380-400. ISSN 2231086X
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Abstract
In the G protein-coupled receptors (GPCRs) relatively short regions of their intracellular loops and cytoplasmic C-terminal domain are responsible for specific interaction with G-proteins. GPCR-derived peptides corresponding to these regions are able to influence the activity of signal pathways involving the cognate receptors. Modified by hydrophobic radicals, these peptides turn into their cell-penetrating analogs, pepducins, possessing the activity both in vitro and in vivo. This review is devoted to the analysis of the available data and the prospects for GPCR-peptides and their lipophilic derivatives to be used in experimental and clinical medicine in the treatment of vascular diseases, cancers, inflammation, and endocrine dysfunctions.
Item Type: | Article |
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Subjects: | Eprints STM archive > Social Sciences and Humanities |
Depositing User: | Unnamed user with email admin@eprints.stmarchive |
Date Deposited: | 27 Jun 2023 07:09 |
Last Modified: | 08 Jan 2024 05:55 |
URI: | http://public.paper4promo.com/id/eprint/723 |