Paraoxonase Role in Human Neurodegenerative Diseases

Reichert, Cadiele Oliana and Levy, Debora and Bydlowski, Sergio P. (2020) Paraoxonase Role in Human Neurodegenerative Diseases. Antioxidants, 10 (1). p. 11. ISSN 2076-3921

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Abstract

The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes. The PONs genetic cluster is made up of three members (PON1, PON2, PON3) that share a structural homology, located adjacent to chromosome seven. The most studied enzyme is PON1, which is associated with high density lipoprotein (HDL), having paraoxonase, arylesterase and lactonase activities. Due to these characteristics, the enzyme PON1 has been associated with the development of neurodegenerative diseases. Here we update the knowledge about the association of PON enzymes and their polymorphisms and the development of multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and Parkinson’s disease (PD).

Item Type: Article
Subjects: Eprints STM archive > Agricultural and Food Science
Depositing User: Unnamed user with email admin@eprints.stmarchive
Date Deposited: 05 Jul 2023 05:17
Last Modified: 30 Oct 2023 04:53
URI: http://public.paper4promo.com/id/eprint/808

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