REGIOSPECIFIC SYNTHESIS AND RATIONALIZATION OF THE REGIODIVERGENCE SOME SPIROOXINDOLES AS EXPECTED ANTIOXIDANT AGENTS

Rizk, Sameh A. and Mahmoud, Naglaa F. and Abdelsattar, Noueldin A. and Ali, Mai S. (2016) REGIOSPECIFIC SYNTHESIS AND RATIONALIZATION OF THE REGIODIVERGENCE SOME SPIROOXINDOLES AS EXPECTED ANTIOXIDANT AGENTS. Al-Azhar Bulletin of Science, 27 (1). pp. 41-46. ISSN 1110-2535

[thumbnail of ABSB_Volume 27_Issue Issue 1-A_Pages 41-46.pdf]

Text
ABSB_Volume 27_Issue Issue 1-A_Pages 41-46.pdf - Published Version
Download (404kB)

Official URL: https://doi.org/10.21608/absb.2016.24329

Abstract

The spirooxindolo pyrrolidine frameworks form core units of many naturally occurring molecules possess significant pharmacological activities. The [3+2] cycloaddition reactions of azomethine ylides has been realized through multi-component reaction (MCR) affording regiospecific spiroindoline-3, 2’-pyrrolidine derivatives. The reactivity of the spiroindoline (increase EHOMO value) has been depended upon electron repelling and attracting groups. The behavior of spiroindoline towards carbon electrophile and nitrogen nucleophile can be investigated. All compound structures are fully supported by spectroscopic data and elemental analysis.The antioxidant activity for these synthesized compounds could be expected that highly antioxidant activity was with compounds which proved to possess high HOMO values

Item Type:	Article
Subjects:	Eprints STM archive > Medical Science
Depositing User:	Unnamed user with email admin@eprints.stmarchive
Date Deposited:	17 Jul 2023 06:19
Last Modified:	04 Oct 2023 05:21
URI:	http://public.paper4promo.com/id/eprint/902

Actions (login required)

: View Item